GDNF polyclonal antibody
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Immunohistochemistry
Immunohistochemical staining of Glial Derived Neurotrophic Factor (GDNF) in rat dorsal root ganglia using GDNF polyclonal antibody (Cat # PAB14339).
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Specification
Product Description
Sheep polyclonal antibody raised against recombinant GDNF.
Immunogen
Recombinant protein corresponding to human GDNF.
Host
Sheep
Reactivity
Human, Mouse, Rat
Specificity
No cross reactivity with NTN has been observed in western blot analysis.
Form
Lyophilized
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 50 uL of sterile water, store at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunohistochemical staining of Glial Derived Neurotrophic Factor (GDNF) in rat dorsal root ganglia using GDNF polyclonal antibody (Cat # PAB14339). -
Gene Info — GDNF
Entrez GeneID
2668Protein Accession#
P39905Gene Name
GDNF
Gene Alias
ATF1, ATF2, HFB1-GDNF
Gene Description
glial cell derived neurotrophic factor
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq
Other Designations
astrocyte-derived trophic factor|glial cell line derived neurotrophic factor|glial derived neurotrophic factor
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Interactome
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Disease
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Publication Reference
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F.
Science 1993 May; 260(5111):1130.
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
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