TARDBP polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of L1210 cells with 2 ug/mL TARDBP polyclonal antibody (Cat # PAB13284).
Immunocytochemistry
Immunocytochemistry of TARDBP in HeLa cells with TARDBP polyclonal antibody (Cat # PAB13284) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TARDBP.
Immunogen
A synthetic peptide corresponding to 18 amino acids near internal region of human TARDBP.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
At least two isoforms are known to exist for this protein; this TDP43 antibody only recongizes the longer of the two isoforms.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (0.5-2 ug/mL)
Immunocytochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of L1210 cells with 2 ug/mL TARDBP polyclonal antibody (Cat # PAB13284).Western Blot
Immunocytochemistry
Immunocytochemistry of TARDBP in HeLa cells with TARDBP polyclonal antibody (Cat # PAB13284) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — TARDBP
Entrez GeneID
23435Protein Accession#
ABO32290Gene Name
TARDBP
Gene Alias
ALS10, TDP-43
Gene Description
TAR DNA binding protein
Omim ID
605078Gene Ontology
HyperlinkGene Summary
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq
Other Designations
OTTHUMP00000002171|TAR DNA-binding protein-43
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Interactome
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Disease
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Publication Reference
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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM.
Science 2006 Oct; 314(5796):130.
Application：IF, IHC, WB-Ti, Human, Human brain.
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Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping.
Buratti E, Dork T, Zuccato E, Pagani F, Romano M, Baralle FE.
The EMBO Journal 2001 Apr; 20(7):1774.
Application：IP, WB, Human, HeLa cells.
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Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
Ou SH, Wu F, Harrich D, García-Martínez LF, Gaynor RB.
Journal of Virology 1995 Jun; 69(6):3584.
Application：WB-Ce, Human, HeLa cells.
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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
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