TNFRSF10A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFRSF10A.
Immunogen
A synthetic peptide corresponding to amino acids 1-20 of human TNFRSF10A.
Host
Rabbit
Reactivity
Human
Specificity
DR4 antibody has no cross reaction to DR5.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TNFRSF10A in HeLa (H), K-562 (K), and Jurkat (J) whole cell lysate with TNFRSF10A polyclonal antibody (Cat # PAB13070) at 1 : 500 dilution. -
Gene Info — TNFRSF10A
Entrez GeneID
8797Protein Accession#
AAC51226Gene Name
TNFRSF10A
Gene Alias
APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Gene Description
tumor necrosis factor receptor superfamily, member 10a
Omim ID
603611Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq
Other Designations
TNF-related apoptosis inducing ligand receptor 1|cytotoxic TRAIL receptor|death receptor 4
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Interactome
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Pathway
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Disease
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Publication Reference
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TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J.
Immunity 1997 Dec; 7(6):831.
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The receptor for the cytotoxic ligand TRAIL.
Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM.
Science 1997 Apr; 276(5309):111.
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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A.
The Journal of Biological Chemistry 1996 May; 271(22):12687.
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TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
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