STIM1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of STIM1 in mouse thymus tissue lysate with STIM1 polyclonal antibody (Cat # PAB12992) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of STIM1 in human spleen tissue with STIM1 polyclonal antibody (Cat # PAB12992) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STIM1.
Immunogen
A synthetic peptide corresponding to C-terminus 24 amino acids of human STIM1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of STIM1 in mouse thymus tissue lysate with STIM1 polyclonal antibody (Cat # PAB12992) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of STIM1 in human spleen tissue with STIM1 polyclonal antibody (Cat # PAB12992) at 2.5 ug/mL . -
Gene Info — STIM1
Entrez GeneID
6786Protein Accession#
NP_003147Gene Name
STIM1
Gene Alias
D11S4896E, GOK
Gene Description
stromal interaction molecule 1
Omim ID
605921Gene Ontology
HyperlinkGene Summary
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene
Other Designations
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Interactome
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Publication Reference
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New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells.
Luik RM, Lewis RS.
Trends in Molecular Medicine 2007 Mar; 13(3):103.
Application：WB-Ce, Human, G401, HL-60, K562, MG63, NFF, SKN-SH, WERI cells.
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STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels.
Spassova MA, Soboloff J, He LP, Xu W, Dziadek MA, Gill DL.
PNAS 2006 Mar; 103(11):4040.
Application：WB-Tr, Human, Rat, RBL, Jurkat cells.
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Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development.
Navas-Martin SR, Weiss S.
Journal of Neurovirology 2004 Apr; 10(2):75.
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New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells.
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