XIAP polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of XIAP in human kidney lysate with XIAP polyclonal antibody (Cat # PAB12923) at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL , respectively.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney tissue using XIAP polyclonal antibody (Cat # PAB12923) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XIAP.
Immunogen
A synthetic peptide corresponding to C-terminus 13 amino acids of human XIAP.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Anti-XIAP is human and mouse reactive.
Form
Liquid
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of XIAP in human kidney lysate with XIAP polyclonal antibody (Cat # PAB12923) at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL , respectively.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney tissue using XIAP polyclonal antibody (Cat # PAB12923) at 2 ug/mL . -
Gene Info — XIAP
Entrez GeneID
331Protein Accession#
NP_001158Gene Name
XIAP
Gene Alias
API3, BIRC4, ILP1, MIHA, XLP2
Gene Description
X-linked inhibitor of apoptosis
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. [provided by RefSeq
Other Designations
OTTHUMP00000023975|OTTHUMP00000196392|apoptosis inhibitor 3|baculoviral IAP repeat-containing 4|baculoviral IAP repeat-containing protein 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.
Holcik M, Yeh C, Korneluk RG, Chow T.
Oncogene 2000 Aug; 19(36):4174.
Application：WB-Ce, WB-Tr, Human, H460, H520, H661, SKOV3 cells.
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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC.
The EMBO Journal 1999 Oct; 18(19):5242.
Application：WB-Tr, Human, HEK 293T cells.
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X-linked IAP is a direct inhibitor of cell-death proteases.
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
Natrue 1997 Jul; 388(6639):300.
Application：WB-Ce, Human, 293T, Jurkat cells.
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Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.
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