CYP19A1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP19A1.
Immunogen
A synthetic peptide corresponding to amino acids 400-502 of human CYP19A1.
Host
Rabbit
Reactivity
Bovine, Horse, Human, Primates, Rabbit
Specificity
This antibody is specific to aromatase.
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CYP19A1 in human fetal temporal lobe lysate using CYP19A1 polyclonal antibody (Cat # PAB12453). ECL exposure, 1-2 minutes. -
Gene Info — CYP19A1
Entrez GeneID
1588Protein Accession#
P11511Gene Name
CYP19A1
Gene Alias
ARO, ARO1, CPV1, CYAR, CYP19, MGC104309, P-450AROM
Gene Description
cytochrome P450, family 19, subfamily A, polypeptide 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000162543|aromatase|cytochrome P450, family 19|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase
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Interactome
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Publication Reference
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Dynamic changes in gene expression that occur during the period of spontaneous functional regression in the rhesus macaque corpus luteum.
Bogan RL, Murphy MJ, Hennebold JD.
Endocrinology 2009 Mar; 150(3):1521.
Application:WB-Ti, Monkey, Frozen corpus luteum.
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Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle.
Bogan RL, Murphy MJ, Stouffer RL, Hennebold JD.
Molecular Endocrinology (Baltimore, Md.) 2008 May; 22(5):1260.
Application:WB-Ti, Monkeyt, Monkey primate corpus luteum tissues.
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Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex.
Beyer C, Green SJ, Barker PJ, Huskisson NS, Hutchison JB.
Brain Research 1994 Feb; 638(1-2):203.
Application:ELISA, IF, IHC, WB, Mouse, Cortex, Hypothalamus, Ovary.
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Dynamic changes in gene expression that occur during the period of spontaneous functional regression in the rhesus macaque corpus luteum.
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