CXCR4 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of SLC10A1 expression from cell extracts with CXCR4 polyclonal antibody (Cat # PAB12323).
Lane 1 : MCF-7 whole cell lysate.
Lane 2 : HeLa whole cell lysate.
Lane 3 : Jurkat whole cell lysate.
Lane 4 : HT1080 whole cell lysate.
Lane 5 : Colo 320 whole cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CXCR4.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human CXCR4.
Host
Rabbit
Theoretical MW (kDa)
39.7, 40.2
Reactivity
Human, Mouse, Rat
Specificity
Different to the related rat sequence by two amino acids.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of SLC10A1 expression from cell extracts with CXCR4 polyclonal antibody (Cat # PAB12323).
Lane 1 : MCF-7 whole cell lysate.
Lane 2 : HeLa whole cell lysate.
Lane 3 : Jurkat whole cell lysate.
Lane 4 : HT1080 whole cell lysate.
Lane 5 : Colo 320 whole cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — CXCR4
Entrez GeneID
7852Gene Name
CXCR4
Gene Alias
CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Gene Description
chemokine (C-X-C motif) receptor 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
C-X-C chemokine receptor type 4|CD184 antigen|chemokine (C-X-C motif), receptor 4 (fusin)|chemokine receptor 4|fusin|leukocyte-derived seven-transmembrane-domain receptor|lipopolysaccharide-associated protein 3|neuropeptide Y receptor Y3|seven transmembra
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Interactome
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Pathway
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Disease
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Publication Reference
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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T.
Nature 1998 Jun; 393(6685):591.
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Genomic organization and promoter characterization of human CXCR4 gene.
Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F.
FEBS Letters 1998 Apr; 426(2):271.
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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
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