RB1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of RB1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of human RB1 polyclonal antibody (Cat # PAB0848) expression in A-431 (A) and K-562 (B) whole cell lysates. -
Gene Info — RB1
Entrez GeneID
5925Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
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Interactome
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Pathway
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Disease
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Publication Reference
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RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling.
Donapaty S, Louis S, Horvath E, Kun J, Sebti SM, Malafa MP.
Molecular Cancer Therapeutics 2006 Feb; 5(2):309.
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RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling.
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