BDNF polyclonal antibody
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More Files
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Immunohistochemistry
Pro - BDNF staining within the rat spinal cord dorsal horn. Normal cryostat sections of adult rat cord were stained with recombinant human anti - proBDNF (Cat # PAB0745) and detected with HRP labelled anti - rabbit antibody. Dilution 1 : 2000 in Human mouse and rat. (Image courtesy of Dr Xin-fu Zhou).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BDNF.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 69-82 of human BDNF.
Sequence
ELLDEDQKVRPNEE
Host
Rabbit
Theoretical MW (kDa)
35
Reactivity
Human, Mouse, Rat
Specificity
Used in western blot, this antiserum detects a 35 KDa band corresponding to the molecular weight of proBDNF. No cross reactivity with other proneurotrophins was detected.
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1-5 ug/mL)
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Pro - BDNF staining within the rat spinal cord dorsal horn. Normal cryostat sections of adult rat cord were stained with recombinant human anti - proBDNF (Cat # PAB0745) and detected with HRP labelled anti - rabbit antibody. Dilution 1 : 2000 in Human mouse and rat. (Image courtesy of Dr Xin-fu Zhou). -
Gene Info — BDNF
Entrez GeneID
627Protein Accession#
P23560Gene Name
BDNF
Gene Alias
MGC34632
Gene Description
brain-derived neurotrophic factor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
Other Designations
neurotrophin
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Interactome
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Pathway
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Disease
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