CD40 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed paraffin-embedded tissue section of human tonsil stained for CD40 expression. Using CD40 polyclonal antibody (Cat # PAB0251) at 1 : 2000. Staining is seen in the dendritic cells. Hematoxylin-eosin counterstain.
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Specification
Product Description
Rabbit polyclonal antibody raised against a recombinant CD40.
Immunogen
Recombinant protein corresponding to short cytoplasmic region of the human CD40.
Host
Rabbit
Reactivity
Dog, Gerbils, Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed paraffin-embedded tissue section of human tonsil stained for CD40 expression. Using CD40 polyclonal antibody (Cat # PAB0251) at 1 : 2000. Staining is seen in the dendritic cells. Hematoxylin-eosin counterstain.Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — CD40
Entrez GeneID
958Gene Name
CD40
Gene Alias
Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Description
CD40 molecule, TNF receptor superfamily member 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|OTTHUMP00000031699|OTTHUMP00000031700|nerve growth factor receptor-related B-lymphocyte activation mol
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Interactome
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Pathway
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Disease
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