The ED50 is < 0.1 ug/mL as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells, corresponding to a specific activity of > 1.0 × 104 IU/mg in the presence of 14 ng/mL of rHuIGF-II.
Recommend Usage:
Biological Activity SDS-PAGE The optimal working dilution should be determined by the end user.
Storage Buffer:
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction:
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Aliquot to avoid repeated freezing and thawing.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq
Other Designations:
IGF-binding protein 4,insulin-like growth factor-binding protein 4