This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq
Other Designations:
IGF-binding protein 1,alpha-pregnancy-associated endometrial globulin,amniotic fluid binding protein,binding protein-25,binding protein-26,binding protein-28,growth hormone independent-binding protein,placental protein 12