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Last updated: 2023/3/26

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IL10RA (Human) Recombinant Protein BioActive

  • Catalog # : P8062
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human IL10RA (Q13651, 22 a.a. - 235 a.a.) partial length recombinant protein with His tag expressed in Baculovirus expression system.
  • Sequence:
  • HGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTN
  • Host:
  • Viruses
  • Theoretical MW (kDa):
  • 25.2
  • Form:
  • Liquid
  • Preparation Method:
  • Baculovirus expression system
  • Purity:
  • > 90% by SDS-PAGE
  • Endotoxin Level:
  • < 1 EU per 1 ug of protein (determined by LAL method)
  • Activity:
  • ED50 is < 300 ng/mL, measured by its ability to inhibit proliferation using MC/9 mouse mast cells with Human IL-10.
  • Quality Control Testing:
  • 3 ug by SDS-PAGE under reducing condition and visualized by Coomassie blue stain.

    QC Testing of P8062
  • Storage Buffer:
  • In Phosphate-Buffer Saline pH 7.4 (20% glycerol)
  • Storage Instruction:
  • Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of bioactivity analysis

  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3587
  • Gene Name:
  • IL10RA
  • Gene Alias:
  • CDW210A,HIL-10R,IL-10R1,IL10R
  • Gene Description:
  • interleukin 10 receptor, alpha
  • Gene Summary:
  • The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq
  • Other Designations:
  • -
  • Related Disease
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