KITLG (Human) Recombinant Protein
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More Files
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Functional Study
The ED50 for this effect is <5 ng/mL, measured by the induction of TF-1 cells proliferation.
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Specification
Product Description
Human KITLG recombinant protein with polyhistidine tag at the C-terminus expressed in Escherichia coli.
Sequence
MEGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVA
Host
Escherichia coli
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ni-NTA chromatography
Purity
> 98% by SDS-PAGE
Endotoxin Level
< 0.1 EU per 1 ug of the protein by the LAL method.
Activity
Measured by the induction of TF-1 cells proliferation. The ED 50 for this effect is < 5 ng/mL. The specific activity of recombinant human SCF is > 5 x 105 IU/mg.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store at -20°C, lyophilized protein is stable for 1 year.
After reconstitution with deionized water, store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
The ED50 for this effect is <5 ng/mL, measured by the induction of TF-1 cells proliferation.SDS-PAGE
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Gene Info — KITLG
Entrez GeneID
4254Gene Name
KITLG
Gene Alias
DKFZp686F2250, KL-1, Kitl, MGF, SCF, SF, SHEP7
Gene Description
KIT ligand
Omim ID
184745Gene Ontology
HyperlinkGene Summary
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
mast cell growth factor|steel factor|stem cell factor
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Interactome
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Pathway
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Disease
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