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Last updated: 2023/5/29

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TNFSF10 (Human) Recombinant Protein BioActive

  • Catalog # : P6951
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  • Specification
  • Product Description:
  • Human TNFSF10 (NP_003801, 114 a.a. - 281 a.a.) partial recombinant protein expressed in Escherichia coli.
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 19.6
  • Form:
  • Liquid
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • > 95% by SDS-PAGE
  • Endotoxin Level:
  • > 1 EU per 1ug of protein (determined by LAL method)
  • Activity:
  • Measured in a cytotoxicity assay using Jurkat human acute T cell leukemia cells. The ED50 range ≤ 1 ng/ml.
  • Quality Control Testing:
  • 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

    QC Testing of P6951
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20mM Tris-HCl, 300 mM NaCl, pH 7.5 (0.1 mM DTT, 10% glycerol)
  • Storage Instruction:
  • Stored at 2°C to 8°C for 1 week.
    For long term storage, aliquot and store at -20°C to -80°C.
    Avoid repeated freezing and thawing cycles.
  • Note:
  • Result of bioactivity analysis

  • TNFSF10 stimulates cell cytotoxicity in the Jurkat human acute T cell leukemia cells. The ED50 range ≤ 1 ng/mL.


  • Applications
  • SDS-PAGE
  • Application Image
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 8743
  • Gene Name:
  • TNFSF10
  • Gene Alias:
  • APO2L,Apo-2L,CD253,TL2,TRAIL
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 10
  • Gene Summary:
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
  • Other Designations:
  • Apo-2 ligand,TNF-related apoptosis inducing ligand TRAIL,tumor necrosis factor (ligand) family, member 10,tumor necrosis factor apoptosis-inducing ligand splice variant delta
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