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Last updated: 2023/3/26

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CSTB (Human) Recombinant Protein BioActive

  • Catalog # : P6940
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  • Specification
  • Product Description:
  • Human CSTB (NP_000091, 1 - 98 a.a.) full length recombinant protein with His tag expressed in Escherichia coli expression system
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 13
  • Form:
  • Liquid
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • > 95% by SDS-PAGE
  • Endotoxin Level:
  • < 1 EU/ug
  • Activity:
  • The IC50 value is < 3.0 nM. The inhibitory function of Cystatin B on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25°C.
  • Quality Control Testing:
  • SDS-PAGE Stained with Coomassie Blue

    QC Testing of P6940
    3 ug SDS-PAGE under reducing condition and visualized by coomassie blue stain.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris-HCl, 50 mM NaCl, pH 8.0
  • Storage Instruction:
  • Store at 4°C for one week. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • SDS-PAGE
  • Application Image
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 1476
  • Gene Name:
  • CSTB
  • Gene Alias:
  • CST6,EPM1,PME,STFB
  • Gene Description:
  • cystatin B (stefin B)
  • Gene Summary:
  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq
  • Other Designations:
  • CPI-B,cystatin B,liver thiol proteinase inhibitor,stefin B
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