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Last updated: 2023/3/26

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GCK (Human) Recombinant Protein BioActive

  • Catalog # : P6833
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  • Specification
  • Product Description:
  • Human Hexokinase 4 protein (NP_000153, 1 a.a.-465 a.a.) full length recombinant protein with His tag expressed in Escherichia coli.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 54.3
  • Form:
  • Liquid
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • > 95% by SDS-PAGE
  • Endotoxin Level:
  • < 1 EU/ug
  • Activity:
  • Specific activity is > 2,000 pmol/min/ug. One unit will convert 1 pmole of D-Glucose to D-Glucose-6-phosphate per minute at pH8.0 at 37°C.
  • Quality Control Testing:
  • 15% SDS-PAGE under reducing condition and visualized by coomassie blue stain.

    QC Testing of P6833
    15% SDS-PAGE under reducing condition and visualized by coomassie blue stain.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris-HCl, pH 8.0 (10% glycerol)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • SDS-PAGE
  • Application Image
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 2645
  • Gene Name:
  • GCK
  • Gene Alias:
  • GK,GLK,HHF3,HK4,HKIV,HXKP,MODY2
  • Gene Description:
  • glucokinase (hexokinase 4)
  • Gene Summary:
  • Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq
  • Other Designations:
  • ATP:D-hexose 6-phosphotransferase,OTTHUMP00000024521,OTTHUMP00000159308,glucokinase,hexokinase D, pancreatic isozyme
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