CASP3 monoclonal antibody, clone SB71b
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Jurkat cells stimulated with (Lane 1) or without (Lane 2) anti-DR5 antibody. Cell lysate wasstained with CASP3 monoclonal antibody, clone SB71b (Cat # MAB8216)-HRP at a 1 :1000 dilution.
-
Specification
Product Description
Mouse monoclonal antibody raised against recombinant CASP3.
Immunogen
Recombinant protein corresponding to human CASP1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.0
Storage Instruction
Store at 4°C.
-
Applications
Western Blot (Cell lysate)
Jurkat cells stimulated with (Lane 1) or without (Lane 2) anti-DR5 antibody. Cell lysate wasstained with CASP3 monoclonal antibody, clone SB71b (Cat # MAB8216)-HRP at a 1 :1000 dilution. -
Gene Info — CASP3
Entrez GeneID
836Gene Name
CASP3
Gene Alias
CPP32, CPP32B, SCA-1
Gene Description
caspase 3, apoptosis-related cysteine peptidase
Omim ID
600636Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000165054|PARP cleavage protease|SREBP cleavage activity 1|Yama|apopain|caspase 3|caspase 3, apoptosis-related cysteine protease|cysteine protease CPP32|procaspase3
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
The enigma of caspase-2: the laymen's view.
Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A.
Cell Death and Differentiation 2008 Nov; 16(2):195.
-
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A.
The Journal of Cell Biology 2002 Apr; 157(3):455.
Application：WB-Tr, Human, HeLa cells.
-
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
Janicke RU, Sprengart ML, Wati MR, Porter AG.
The Journal of Biological Chemistry 1998 Apr; 273(16):9357.
-
The enigma of caspase-2: the laymen's view.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com