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Last updated: 2023/5/29

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Itgal monoclonal antibody, clone M17/4

Catalog # : MAB7916
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Specification

Product Description:
Rat monoclonal antibody raised againt native Itgal.

Immunogen:
Native purified Itgal from C57BL/6 mouse splenic secondary cytotoxic T lymphocytes.

Host:
Rat

Theoretical MW (kDa):
180

Reactivity:
Mouse

Specificity:
This antibody reacts with Itgal (alpha-subunit of murine LFA-1), a180 KDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.

Form:
Liquid

Purification:
Protein-G affinity chromatography.

Isotype:
IgG2a

Recommend Usage:
Immunohistochemistry
Immunoprecipitation
Flow Cytometry (1 ug/mL)
The optimal working dilution should be determined by the end user.

Storage Buffer:
In PBS, pH 7.4 (0.09% sodium azide)

Storage Instruction:
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.

Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Datasheet:
Download

Publication Reference

1.
The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo.
Beyer M, Wang H, Peters N, Doths S, Koerner-Rettberg C, Openshaw PJ, Schwarze J.Respir Res. 2005 Jul 12;6:70.

2.
Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation.
Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S, Haslett C, Mutsaers SE, Laurent GJ.J Exp Med. 2002 Dec 2;196(11):1515-21.

3.
In situ demonstration of intraepithelial lymphocyte adhesion to villus microvessels of the small intestine.
Koseki S, Miura S, Fujimori H, Hokari R, Komoto S, Hara Y, Ogino T, Nagata H, Goto M, Hachimura S, Kaminogawa S, Ishii H.Int Immunol. 2001 Sep;13(9):1165-74.

4.
Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice.
Papayannopoulou T, Priestley GV, Nakamoto B, Zafiropoulos V, Scott LM, Harlan JM.Blood. 2001 Mar 1;97(5):1282-8.

5.
Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice.
Yung R, Powers D, Johnson K, Amento E, Carr D, Laing T, Yang J, Chang S, Hemati N, Richardson B.J Clin Invest. 1996 Jun 15;97(12):2866-71.

Applications

Immunohistochemistry (Frozen sections)

Immunoprecipitation

Functional Study

Blocking

Flow Cytometry

Application Image

Immunohistochemistry (Frozen sections)

Immunoprecipitation

Functional Study

Blocking

Flow Cytometry

Gene Information

Entrez GeneID:
16408

Gene Name:
Itgal

Gene Alias:
Cd11a,LFA-1,Ly-15,Ly-21

Gene Description:
integrin alpha L

Gene Ontology:
Hyperlink

Other Designations:
CD11A (p180),lymphocyte function associated antigen 1, alpha polypeptide

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