CD4 monoclonal antibody, clone QS4120
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Specification
Product Description
Mouse monoclonal antibody raised against CD4.
Immunogen
CD4+ transfectant/ CEM.
Host
Mouse
Reactivity
Human
Specificity
Antibody QS4120 recognizes an epitope in the CDR2-like loop within domain 1 region of the CD4 molecule. Antibody QS4120 will block binding of HIV-1 gp120 protein to CD4 and also blocks HLA Class II Rosette formation.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — CD4
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Interactome
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Pathway
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Disease
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Publication Reference
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A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.
Helling B, Konig M, Dalken B, Engling A, Kromer W, Heim K, Wallmeier H, Haas J, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, Osterroth F, Uherek C, Czeloth N, Schuttrumpf J.
Immunology and Cell Biology 2015 Apr; 93(4):396.
Application:Func, Human, Human T cells.
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Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.
Dornan S, Sebestyen Z, Gamble J, Nagy P, Bodnar A, Alldridge L, Doe S, Holmes N, Goff LK, Beverley P, Szollosi J, Alexander DR.
The Journal of Biological Chemistry 2002 Jan; 277(3):1912.
Application:Flow Cyt, IP, Human, HPB-ALL cells.
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HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.
Ugolini S, Moulard M, Mondor I, Barois N, Demandolx D, Hoxie J, Brelot A, Alizon M, Davoust J, Sattentau QJ.
Journal of Immunology 1997 Sep; 159(6):3000.
Application:Flow Cyt, Human, A3.01, Mv-1-lu, T cells.
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Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation.
Konig R, Shen X, Germain RN.
The Journal of Experimental Medicine 1995 Sep; 182(3):779.
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A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.
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