CD74 monoclonal antibody, clone PIN.1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of N87 cell lysates mixed with Macrophage inhibitory factor. Using CD74 monoclonal antibody, clone PIN.1 (Cat # MAB6623).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of CD74.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to invariant chain of human CD74.
Host
Mouse
Reactivity
Human
Specificity
Detects~33-35KDa protein doublet corresponding to the molecular mass of the p33 and p35 forms of human CD74 on SDS PAGE immunoblots.
Form
Liquid
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of N87 cell lysates mixed with Macrophage inhibitory factor. Using CD74 monoclonal antibody, clone PIN.1 (Cat # MAB6623).Immunocytochemistry
Immunoprecipitation
Flow Cytometry
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Gene Info — CD74
Entrez GeneID
972Gene Name
CD74
Gene Alias
DHLAG, HLADG, Ia-GAMMA
Gene Description
CD74 molecule, major histocompatibility complex, class II invariant chain
Omim ID
142790Gene Ontology
HyperlinkGene Summary
major histocompatibility complex
Other Designations
CD74 antigen|CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)|HLA-DR-gamma|Ia-associated invariant chain|MHC HLA-DR gamma chain|gamma chain of class II antigens
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Interactome
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Pathway
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Disease
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Publication Reference
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Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.
Starlets D, Gore Y, Binsky I, Haran M, Harpaz N, Shvidel L, Becker-Herman S, Berrebi A, Shachar I.
Blood 2006 Jun; 107(12):4807.
Application：Flow Cyt, Human, Mouse, HEK 293 cells, Mouse splenocytes.
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CD74 is a member of the regulated intramembrane proteolysis-processed protein family.
Becker-Herman S, Arie G, Medvedovsky H, Kerem A, Shachar I.
Molecular Biology of the Cell 2005 Nov; 16(11):5061.
Application：IF, WB-Tr, Human, HEK 293 cells.
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Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.
Denzin LK, Robbins NF, Carboy-Newcomb C, Cresswell P.
Immunity 1994 Oct; 1(7):595.
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Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.
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