CD9 monoclonal antibody, clone MEM-61 (APC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD9.
Immunogen
Native purified CD9 from Pre-B cell line NALM-6.
Host
Mouse
Theoretical MW (kDa)
24
Reactivity
Human
Specificity
This antibody recognizes an epitope on second extracellular domain (EC2) of CD9 antigen, a 24 KDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes.
Form
Liquid
Conjugation
APC
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD9
Entrez GeneID
928Gene Name
CD9
Gene Alias
5H9, BA2, BTCC-1, DRAP-27, GIG2, MIC3, MRP-1, P24, TSPAN29
Gene Description
CD9 molecule
Omim ID
143030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance. [provided by RefSeq
Other Designations
5H9 antigen|CD9 antigen|CD9 antigen (p24)|OTTHUMP00000041574|OTTHUMP00000041576|antigen defined by monoclonal antibody 602-29|growth-inhibiting gene 2 protein|leukocyte antigen MIC3|motility related protein|motility related protein-1|p24 antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals.
Keisuke Fukuchi, Kayoko Nanai, Hiroshi Yuita, Chikako Maru, Jun Tsukada, Masato Ishigami, Yoko Nagai, Yoko Nakano, Chigusa Yoshimura, Kozo Yoneda, Masato Amano, Kensuke Nakamura, Yoko Oda, Haruyuki Nishigohri, Shoji Yamamoto, Yusuke Ohnishi-Totoki, Koichiro Inaki, Hironobu Komori, Rika Nakano, Yoshiyuki Kanari, Atsuko Nishida, Yumi Matsui, Satoko Funo, Sayako Takahashi, Toshiaki Ohtsuka, Toshinori Agatsuma.
Journal of Oncology 2022 Nov; 2022:3552793.
Application：Flow Cyt, Human, MIA PaCa-2 cells.
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Platelet tetraspanin complexes and their association with lipid rafts.
Israels SJ, McMillan-Ward EM.
Thrombosis and Haemostasis 2007 Nov; 98(5):1081.
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Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells.
Kim YJ, Yu JM, Joo HJ, Kim HK, Cho HH, Bae YC, Jung JS.
Pflugers Archiv: European Journal of Physiology 2007 Aug; 455(2):283.
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The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.
Unternaehrer JJ, Chow A, Pypaert M, Inaba K, Mellman I.
PNAS 2006 Dec; 104(1):234.
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Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals.
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