CD33 monoclonal antibody, clone HIM3-4 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD33.
Immunogen
Native purified CD33 from human cell line NFMY-9s.
Host
Mouse
Theoretical MW (kDa)
67
Reactivity
Human, Non-Human Primates
Specificity
This antibody reacts with CD33, a 67 KDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells; it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Form
Liquid
Conjugation
Biotin
Isotype
IgG1
Recommend Usage
Flow Cytometry (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD33
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor.
Walter RB, Hausermann P, Raden BW, Teckchandani AM, Kamikura DM, Bernstein ID, Cooper JA.
Traffic (Copenhagen, Denmark) 2007 Dec; 9(2):267.
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CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.
Orr SJ, Morgan NM, Elliott J, Burrows JF, Scott CJ, McVicar DW, Johnston JA.
Blood 2006 Sep; 109(3):1061.
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The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.
Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML.
European Journal of Immunology 1999 Nov; 29(11):3440.
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Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor.
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