BSG monoclonal antibody, clone MEM-M6/1
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant BSG.
Immunogen
Recombinant Fc fusion protein corresponding to human BSG.
Host
Mouse
Theoretical MW (kDa)
50-60
Reactivity
Human
Specificity
This antibody recognizes an epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 KDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes.
This antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — BSG
Entrez GeneID
682Gene Name
BSG
Gene Alias
5F7, CD147, EMMPRIN, M6, OK, TCSF
Gene Description
basigin (Ok blood group)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD147 antigen|M6 leukocyte activation antigen|OK blood group antigen|basigin|collagenase stimulatory factor|extracellular matrix metalloproteinase inducer
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Interactome
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Disease
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Publication Reference
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Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes.
Schmidt R, Bultmann A, Fischel S, Gillitzer A, Cullen P, Walch A, Jost P, Ungerer M, Tolley ND, Lindemann S, Gawaz M, Schomig A, May AE.
Circulation Research 2007 Nov; 102(3):302.
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Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases.
Melchior A, Denys A, Deligny A, Mazurier J, Allain F.
Experimental Cell Research 2007 Nov; 314(3):616.
Application：IP, Human, THP-1 cells.
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T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density.
Koch C, Staffler G, Huttinger R, Hilgert I, Prager E, Cerny J, Steinlein P, Majdic O, Horejsi V, Stockinger H.
International Immunology 1999 May; 11(5):777.
Application：WB-Ce, Human, Human fibroblastoid 293 cells.
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Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes.
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