COMP monoclonal antibody, clone 6G5
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Specification
Product Description
Mouse monoclonal antibody raised against COMP.
Immunogen
Native purified COMP from normal human cartilage.
Host
Mouse
Reactivity
Human
Specificity
Reacts with both reduced and non-reduced human COMP.
Form
Liquid
Isotype
IgM
Recommend Usage
ELISA (1:5-1:10)
Western Blot (1:1-1:3)
The optimal working dilution should be determined by the end user.Storage Buffer
In culture supernatant (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — COMP
Entrez GeneID
1311Gene Name
COMP
Gene Alias
EDM1, EPD1, MED, MGC131819, MGC149768, PSACH, THBS5
Gene Description
cartilage oligomeric matrix protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq
Other Designations
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|pseudoachondroplasia (epiphyseal dysplasia 1, multiple)|thrombospondin
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Interactome
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Pathway
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Disease
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