Flow cytometric analysis of Ramos cells with JAK3 (phospho Y980/981) monoclonal antibody, clone E10 (APC) (Cat # MAB23568). Unstained (red) or treated with pervanadate (green). Concentration matched isotype control Cat #2144 for cells untreated (black) or treated with pervanadate (blue).
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq