Western Blot analysis of COS7 cell lysate with JAK3 (phospho Y980/981) monoclonal antibody, clone CF12 (Cat # MAB23565). Lane 1: untreated or Lane 2: treated with pervanadate.
Flow Cytometry
Flow cytometric analysis of Ramos cells with JAK3 (phospho Y980/981) monoclonal antibody, clone E10 (Cat # MAB23565). Secondary antibody only negative control (blue) or untreated (red) or treated with pervanadate (green).
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq