PKCG (phospho T514) monoclonal antibody, clone PF4 (PE)
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PKC gamma.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding T514 of human PKC gamma.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
PE
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of HT1080 cells with PKCG (phospho T514) monoclonal antibody, clone PF4 (PE) (Cat # MAB23562). Treated with staurosporine (red) or untreated (green). Concentration matched isotype control Cat #2142 for treated with staurosporine (black) or untreated (blue). -
Gene Info — PRKCG
Entrez GeneID
5582Protein Accession#
P17252 P05771 P05771-2 Q05655 Q02156 P24723 P05129 Q04759Gene Name
PRKCG
Gene Alias
MGC57564, PKC-gamma, PKCC, PKCG, SCA14
Gene Description
protein kinase C, gamma
Gene Ontology
HyperlinkGene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq
Other Designations
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