Flow cytometric analysis of C6 cells with MARCKS (phospho S167/170) monoclonal antibody, clone C9 (FITC) (Cat # MAB23559). Treated with staurosporine (red) or treated with UV+TPA (green). Concentration matched isotype control Cat #2143 for treated with staurosporine (black) or treated with UV TPA (blue).
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq
Other Designations:
OTTHUMP00000017045,myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L),phosphomyristin