LMNA (phospho S22) monoclonal antibody, clone CF12 (APC)
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More Files
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Flow Cytometry
Flow cytometric analysis of HeLa cells with LMNA (phospho S22) monoclonal antibody, clone CF12 (APC) (Cat # MAB23553). Unstained as untreated (red) or treated (green), concentration matched isotype control Cat #2144 for untreated (black) or treated with nocodazole (blue).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human LMNA.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding S22 of human Lamin A/C.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of HeLa cells with LMNA (phospho S22) monoclonal antibody, clone CF12 (APC) (Cat # MAB23553). Unstained as untreated (red) or treated (green), concentration matched isotype control Cat #2144 for untreated (black) or treated with nocodazole (blue). -
Gene Info — LMNA
Entrez GeneID
4000Protein Accession#
P02545Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
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Interactome
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Pathway
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Disease
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