Flow cytometric analysis of HeLa cells with FOS (phospho S32) monoclonal antibody, clone BA9 (Cat # MAB23542). Unstained as negative control (blue) or untreated (red) or treated with UV+TPA (green).
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq