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Entrez GeneID

Protein Accession#

Gene Name

AURKA

Gene Alias

AIK, ARK1, AURA, AURORA2, BTAK, MGC34538, STK15, STK6, STK7

Gene Description

aurora kinase A

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations

IPL1-related kinase|OTTHUMP00000031340|OTTHUMP00000031342|OTTHUMP00000031343|OTTHUMP00000031344|OTTHUMP00000031345|OTTHUMP00000166071|aurora-A|aurora-related kinase 1|aurora/IPL1-like kinase|breast-tumor-amplified kinase|serine/threonine kinase 15|serine/

Entrez GeneID

Protein Accession#

Gene Name

AURKC

Gene Alias

AIE2, AIK3, AurC, STK13, aurora-C

Gene Description

aurora kinase C

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq

Other Designations

aurora/IPL1-related kinase 3|aurora/IPL1/EG2 protein 2|serine/threonine kinase 13 (aurora/IPL1-like)

Entrez GeneID

Protein Accession#

Gene Name

AURKB

Gene Alias

AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5

Gene Description

aurora kinase B

Omim ID

Gene Ontology

Gene Summary

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM

Other Designations

aurora-1|aurora-B|serine/threonine kinase 12