Flow cytometric analysis of Ramos cells with BTK (phospho Y551) monoclonal antibody, clone G12 (SureLight 488) (Cat # MAB23497). Unstained and untreated as negative control (blue) or stained untreated (red) or treated with pervanadate (green).
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq