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MAP3K5 (phospho S83) monoclonal antibody, clone G4 (APC) 

  • Catalog # : MAB23436
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MAP3K5
  • Immunogen:
  • A synthetic phosphopeptide corresponding to residues surrounding S83 of human MAP3K5.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Conjugation:
  • APC
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (5 uL/106 cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HT-1080 human fibrosarcoma unstained cells with MAP3K5 (phospho S83) monoclonal antibody, clone G4 (APC) (Cat # MAB23436). Unstained treated with imatinib as negative control (blue) or stained treated with imatinib (red) or treated with pervanadate (green).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 4217
  • Gene Name:
  • MAP3K5
  • Gene Alias:
  • ASK1,MAPKKK5,MEKK5
  • Gene Description:
  • mitogen-activated protein kinase kinase kinase 5
  • Gene Summary:
  • Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq
  • Other Designations:
  • MAP/ERK kinase kinase 5,MAPK/ERK kinase kinase 5,OTTHUMP00000017275,apoptosis signal regulating kinase
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