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ZAP70/SYK (phospho Y319) monoclonal antibody, clone A3 (FITC ) 

  • Catalog # : MAB23430
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human ZAP70/SYK
  • Immunogen:
  • A synthetic phosphopeptide corresponding to residues surrounding Y319 of human ZAP70/SYK.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Conjugation:
  • FITC
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (5 uL/106 cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of Jurkat cells with ZAP70/SYK (phospho Y319) monoclonal antibody, clone A3 (FITC ) (Cat # MAB23430). Untreated (red) or treated with pervanadate (green) or concentration-matched Rabbit (G9) mAb IgG Isotype Control (PE Conjugate) for cells untreated (black) or treated with pervanadate (blue).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 7535
  • Gene Name:
  • ZAP70
  • Gene Alias:
  • FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70
  • Gene Description:
  • zeta-chain (TCR) associated protein kinase 70kDa
  • Gene Summary:
  • This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • syk-related tyrosine kinase,zeta-chain (TCR) associated protein kinase (70 kD),zeta-chain associated protein kinase 70kDa,zeta-chain associated protein kinase, 70kD
  • Gene Information
  • Entrez GeneID:
  • 6850
  • Gene Name:
  • SYK
  • Gene Alias:
  • DKFZp313N1010,FLJ25043,FLJ37489
  • Gene Description:
  • spleen tyrosine kinase
  • Other Designations:
  • OTTHUMP00000021627,OTTHUMP00000021628
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