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Last updated: 2023/3/26

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MAP2K3 (phospho S189/S207) monoclonal antibody, clone D3 (FITC) 

  • Catalog # : MAB23420
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MAP2K3.
  • Immunogen:
  • A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Conjugation:
  • FITC
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (5 uL/million cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% NaN3, 0.2% BSA)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HEK293 cells with MAP2K3 (phospho S189/S207) monoclonal antibody, clone D3 (FITC)(Cat # MAB23420). Treated with K252a (red) or treated with UV+TPA (green)
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 5606
  • Gene Name:
  • MAP2K3
  • Gene Alias:
  • MAPKK3,MEK3,MKK3,PRKMK3
  • Gene Description:
  • mitogen-activated protein kinase kinase 3
  • Gene Summary:
  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq
  • Other Designations:
  • MAP kinase kinase 3,MAPK/ERK kinase 3,OTTHUMP00000166044,dual specificity mitogen activated protein kinase kinase 3
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