Flow cytometric analysis of C6 cells with CBL (phospho Tyr700) monoclonal antibody, clone E1 (FITC)(Cat # MAB23391). Unstained as negative control (blue) or treated with imatinib (red) or with pervanadate (green)
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq