MCM2 (phospho S139) monoclonal antibody, clone B12 (FITC)
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More Files
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Flow Cytometry
Flow cytometric analysis of C6 cells with MCM2 (phospho Ser139) monoclonal antibody, clone B12 (FITC)(Cat # MAB23381). Unstained as negative control (blue) or untreated (red) or treated with staurosporine (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MCM2.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho MCM2
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
FITC
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/million cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% NaN3, 0.2% BSA)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of C6 cells with MCM2 (phospho Ser139) monoclonal antibody, clone B12 (FITC)(Cat # MAB23381). Unstained as negative control (blue) or untreated (red) or treated with staurosporine (green). -
Gene Info — MCM2
Entrez GeneID
4171Protein Accession#
P49736Gene Name
MCM2
Gene Alias
BM28, CCNL1, CDCL1, D3S3194, KIAA0030, MGC10606, MITOTIN, cdc19
Gene Description
minichromosome maintenance complex component 2
Omim ID
116945Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. [provided by RefSeq
Other Designations
DNA replication licensing factor MCM2|MCM2 minichromosome maintenance deficient 2, mitotin|cell devision cycle-like 1|cyclin-like 1|minichromosome maintenance deficient 2 (mitotin)|nuclear protein BM28
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Interactome
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Disease
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