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Last updated: 2023/3/26

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MAPK8 (phospho T183/Y185) monoclonal antibody, clone A11 (PE) 

  • Catalog # : MAB23372
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MAPK8.
  • Immunogen:
  • A synthetic phospho-peptide corresponding to residues surrounding Thr183/Tyr185 of human phospho SAPK/JNK
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (5 uL/million cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% NaN3, 0.2% BSA)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of 293T cells with MAPK8 (phospho Thr183/Tyr185) monoclonal antibody, clone A11 (PE)(Cat # MAB23372). Unstained as negative control (blue) or untreated (red) or with UV+TPA (green)
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 5599
  • Gene Name:
  • MAPK8
  • Gene Alias:
  • JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1
  • Gene Description:
  • mitogen-activated protein kinase 8
  • Gene Summary:
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • JNK1 alpha protein kinase,JNK1 beta protein kinase,JUN N-terminal kinase,OTTHUMP00000019552,OTTHUMP00000019555,OTTHUMP00000019556,OTTHUMP00000019558,c-Jun N-terminal kinase 1,mitogen-activated protein kinase 8 isoform JNK1 alpha1,mitogen-activated protein
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