Flow cytometric analysis of THP1 cells with NDRG1 (phospho Thr346) monoclonal antibody, clone F5 (FITC)(Cat # MAB23365). Unstained and untreated as negative control (blue) or untreated (red) or treated with IFNa plus IL-4 and pervanadate (green).
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations:
differentiation-related gene 1 protein,nickel-specific induction protein Cap43,protein regulated by oxygen-1,reducing agents and tunicamycin-responsive protein,tunicamycin-responsive protein