CRKL (phospho Y207) monoclonal antibody, clone G4 (FITC)
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More Files
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Flow Cytometry
Flow cytometric analysis of K562 cells with CRKL (phospho Tyr207) monoclonal antibody, clone G4 (FITC)(Cat # MAB23354). Unstained and treated with imatinib as negative control (blue) or treated imatinib (red) or treated with pervanadate (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human CRKL.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human phospho CrkL
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
FITC
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/million cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% NaN3, 0.2% BSA)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of K562 cells with CRKL (phospho Tyr207) monoclonal antibody, clone G4 (FITC)(Cat # MAB23354). Unstained and treated with imatinib as negative control (blue) or treated imatinib (red) or treated with pervanadate (green). -
Gene Info — CRKL
Entrez GeneID
1399Protein Accession#
P46109Gene Name
CRKL
Gene Alias
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Gene Description
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Omim ID
602007Gene Ontology
HyperlinkGene Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic
Other Designations
v-crk avian sarcoma virus CT10 oncogene homolog-like
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Interactome
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Pathway
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Disease
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