STAT3 monoclonal antibody, clone RM465
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysates with STAT3 monoclonal antibody, clone RM465 (Cat # MAB23247) at a 1:1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer with STAT3 monoclonal antibody, clone RM465 (Cat # MAB23247) at a 1:50 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with STAT3 monoclonal antibody, clone RM465 (Cat # MAB23247) at a 1:200 dilution.
Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using STAT3 monoclonal antibody, clone RM465 (Cat# MAB23247) at 1:50 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human STAT3.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to N-terminus of human STAT3.
Reactivity
Human
Specificity
This antibody reacts to human STAT3. This antibody may also react to mouse or rat Stat3, as predicted by immunogen homology.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysates with STAT3 monoclonal antibody, clone RM465 (Cat # MAB23247) at a 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer with STAT3 monoclonal antibody, clone RM465 (Cat # MAB23247) at a 1:50 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with STAT3 monoclonal antibody, clone RM465 (Cat # MAB23247) at a 1:200 dilution.Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using STAT3 monoclonal antibody, clone RM465 (Cat# MAB23247) at 1:50 dilution. -
Gene Info — STAT3
Entrez GeneID
6774Gene Name
STAT3
Gene Alias
APRF, FLJ20882, HIES, MGC16063
Gene Description
signal transducer and activator of transcription 3 (acute-phase response factor)
Omim ID
102582Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
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