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AURKA/AURKB/AURKC (phospho T288/T232/T198) monoclonal antibody, clone RM454 

  • Catalog # : MAB23238
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human AURKA/AURKB/AURKC.
  • Immunogen:
  • A synthetic phosphopeptide corresponding to residues surrounding T288/T232/T198 of human AURKA/AURKB/AURKC.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts to human AURKA/AURKB/AURKC only when phosphorylated at either Thr288, Thr232 or Thr198 respectively. There is no cross-reactivity to AURKA/AURKB/AURKC that is not phosphorylated.
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:200)
    Western Blot (1:1000-1:3000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (50% glycerol, 1% BSA, 0.09% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of HeLa cell lysates with AURKA/AURKB/AURKC (phospho T288/T232/T198) monoclonal antibody, clone RM454 (Cat # MAB23238) at a 1:2500 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with AURKA/AURKB/AURKC (phospho T288/T232/T198) monoclonal antibody, clone RM454 (Cat # MAB23238) at a 1:50 dilution.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 6790
  • Gene Name:
  • AURKA
  • Gene Alias:
  • AIK,ARK1,AURA,AURORA2,BTAK,MGC34538,STK15,STK6,STK7
  • Gene Description:
  • aurora kinase A
  • Gene Summary:
  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
  • Other Designations:
  • IPL1-related kinase,OTTHUMP00000031340,OTTHUMP00000031342,OTTHUMP00000031343,OTTHUMP00000031344,OTTHUMP00000031345,OTTHUMP00000166071,aurora-A,aurora-related kinase 1,aurora/IPL1-like kinase,breast-tumor-amplified kinase,serine/threonine kinase 15,serine/
  • Gene Information
  • Entrez GeneID:
  • 9212
  • Gene Name:
  • AURKB
  • Gene Alias:
  • AIK2,AIM-1,AIM1,ARK2,AurB,IPL1,STK12,STK5
  • Gene Description:
  • aurora kinase B
  • Gene Summary:
  • Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
  • Other Designations:
  • aurora-1,aurora-B,serine/threonine kinase 12
  • Gene Information
  • Entrez GeneID:
  • 6795
  • Gene Name:
  • AURKC
  • Gene Alias:
  • AIE2,AIK3,AurC,STK13,aurora-C
  • Gene Description:
  • aurora kinase C
  • Gene Summary:
  • This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq
  • Other Designations:
  • aurora/IPL1-related kinase 3,aurora/IPL1/EG2 protein 2,serine/threonine kinase 13 (aurora/IPL1-like)
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