NTRK1 monoclonal antibody, clone RM423
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot of mouse brain tissue lysate using NTRK1 monoclonal antibody clone RM423 at a 1:2000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using NTRK1 monoclonal antibody clone RM423 at a 1:100 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human NTRK1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to the C-terminus of human NTRK1.
Reactivity
Human
Specificity
This antibody reacts to human NTRK1. This antibody may also react to mouse or rat Ntrk1, as predicted by immunogen homology.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunochemistry (1:100 - 1:400)
Western Blot (1:1000 - 1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot of mouse brain tissue lysate using NTRK1 monoclonal antibody clone RM423 at a 1:2000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using NTRK1 monoclonal antibody clone RM423 at a 1:100 dilution. -
Gene Info — NTRK1
Entrez GeneID
4914Gene Name
NTRK1
Gene Alias
DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
Gene Description
neurotrophic tyrosine kinase, receptor, type 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Other Designations
OTTHUMP00000038736|Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A
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Interactome
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Pathway
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Disease
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