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Last updated: 2023/5/29

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CD1C monoclonal antibody, clone M241 

  • Catalog # : MAB22942
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD1C.
  • Immunogen:
  • Human T cell line Molt 4.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific for the CD1c molecule of about 48 kd.
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry
    Immunohistochemistry (Frozen sections)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 50 mM sodium phosphate buffer, 100 mM potassium chloride, 150 mM NaCl, pH 7.5.
  • Storage Instruction:
  • Store at 4°C.
    Do not freeze.
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Flow Cytometry
  • Five x 105 cultured human Molt-4 cells per tube were incubated 45 minutes on ice with 80 uL anti-CD1c antibody at 10 ug/mL. Cells were washed twice and incubated with secondary reagent goat anti-mouse IgG/FITC at a 1:60 dilution factor, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.45 log10 fluorescent units when compared to a mouse IgG1 negative control at a similar concentration.
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 911
  • Gene Name:
  • CD1C
  • Gene Alias:
  • BDCA1,CD1,CD1A,R7
  • Gene Description:
  • CD1c molecule
  • Gene Summary:
  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq
  • Other Designations:
  • CD1C antigen,CD1C antigen, c polypeptide,OTTHUMP00000018909,T-cell surface glycoprotein CD1c,cortical thymocyte antigen CD1C,differentiation antigen CD1-alpha-3
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