FURIN monoclonal antibody, clone AEGA-6
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human FURIN.
Immunogen
A synthetic peptide corresponding to human FURIN.
Host
Rabbit
Reactivity
Human
Specificity
The antibody reacts with human FURIN, in native form and recombinant. Superfamily members of FURIN are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate.Immunohistochemistry
Immunocytochemistry
Immunofluorescence
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Gene Info — FURIN
Entrez GeneID
5045Protein Accession#
P09958Gene Name
FURIN
Gene Alias
FUR, PACE, PCSK3, SPC1
Gene Description
furin (paired basic amino acid cleaving enzyme)
Omim ID
136950Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq
Other Designations
FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)|proprotein convertase subtilisin/kexin type 3
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Interactome
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Disease
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