The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. [provided by RefSeq
Other Designations:
PTH/PTHr receptor,PTH/PTHrP type I receptor,parathyroid hormone receptor 1,parathyroid hormone/parathyroid hormone-related peptide receptor,parathyroid hormone/parathyroid hormone-related protein receptor,seven transmembrane helix receptor