RAD50 monoclonal antibody, clone ACCG-18
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human RAD50.
Immunogen
A synthetic peptide corresponding to human RAD50.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
A synthesized peptide derived from human Rad50 Component of the MRN complex.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1:50-200)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of RAD50.Immunofluorescence
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Gene Info — RAD50
Entrez GeneID
10111Protein Accession#
Q92878Gene Name
RAD50
Gene Alias
RAD50-2, hRad50
Gene Description
RAD50 homolog (S. cerevisiae)
Omim ID
604040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000065928|RAD50 homolog
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Interactome
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