TARDBP monoclonal antibody, clone k1B8
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of human prostate cancer and seminoma tissue.
Flow Cytometry
Flow cytometric analysis of HeLa cell line, staining at 2-5 ug for 1x106cells. The secondary antibody used goat anti-mouse IgG Alexa fluor 488 conjugate
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TARDBP.
Immunogen
Recombinant protein corresponding to amino acids 1-260 of human TARDBP.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Flow Cytometry
Immunohistochemistry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of human prostate cancer and seminoma tissue.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of HeLa cell line, staining at 2-5 ug for 1x106cells. The secondary antibody used goat anti-mouse IgG Alexa fluor 488 conjugate -
Gene Info — TARDBP
Entrez GeneID
23435Protein Accession#
NP_031401Gene Name
TARDBP
Gene Alias
ALS10, TDP-43
Gene Description
TAR DNA binding protein
Omim ID
605078Gene Ontology
HyperlinkGene Summary
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq
Other Designations
OTTHUMP00000002171|TAR DNA-binding protein-43
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Interactome
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Disease
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Publication Reference
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Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.
Verheijen BM, Hashimoto T, Oyanagi K, van Leeuwen FW.
Acta Neuropathologica Communications 2017 Nov; 5(1):82.
Application：IHC-P, Human, Human Guam parkinsonism-dementia complex (G-PDC) brains.
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SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.
Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, Yerbury JJ.
Molecular Neurodegeneration 2015 Oct; 10(1):57.
Application：IF, EM, Mouse, NSC-34 cells.
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Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.
Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, Geschwind DH, Knopman DS, Mitsumoto H, Petersen RC, Cashman NR, Hutton M, Shaw CE, Boylan KB, Boeve B, Graff-Radford NR, Wszolek ZK, Caselli RJ, Dickson DW, Mackenzie IR, Petrucelli L, Rademakers R.
PLoS Genetics 2008 Sep; 4(9):e1000193.
Application：WB, Human, H4 neuroglioma cells.
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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis.
Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Vande Velde C, Bouchard JP, Lacomblez L, Pochigaeva K, Salachas F, Pradat PF, Camu W, Meininger V, Dupre N, Rouleau GA.
Nature Genetics 2008 May; 40(5):572.
Application：WB, Human, Patients with sporadic and familial amyotrophic lateral sclerosis.
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Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
Ou SH, Wu F, Harrich D, García-Martínez LF, Gaynor RB.
Journal of Virology 1995 Jun; 69(6):3584.
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Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.
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