MET monoclonal antibody, clone 6AT203
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More Files
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Western Blot (Cell lysate)
Detection of endogenous MET in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human MET. Lanes 1-5 represent MET monoclonal antibody, clone 6AT203 (Cat # MAB1144). Lane 6 represents auto-phosohorylated-MET in HepG2 cell line detected by anti-phospho-MET monoclonal antibody (Cat # MAB0115).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant MET.
Immunogen
Recombinant protein corresponding to catalytic region of human MET.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Detection of endogenous MET in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human MET. Lanes 1-5 represent MET monoclonal antibody, clone 6AT203 (Cat # MAB1144). Lane 6 represents auto-phosohorylated-MET in HepG2 cell line detected by anti-phospho-MET monoclonal antibody (Cat # MAB0115). -
Gene Info — MET
Entrez GeneID
4233Protein Accession#
P08581Gene Name
MET
Gene Alias
AUTS9, HGFR, RCCP2, c-Met
Gene Description
met proto-oncogene (hepatocyte growth factor receptor)
Gene Ontology
HyperlinkGene Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HGF receptor|OTTHUMP00000069168|SF receptor|met proto-oncogene|met proto-oncogene tyrosine kinase|oncogene MET|scatter factor receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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MET receptor sequence variants R970C and T992I lack transforming capacity.
Tyner JW, Fletcher LB, Wang EQ, Yang WF, Rutenberg-Schoenberg ML, Beadling C, Mori M, Heinrich MC, Deininger MW, Druker BJ, Loriaux MM.
Cancer Research 2010 Aug; 70(15):6233.
Application：WB-Tr, Human, 293 T17 cells.
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Further evidence for the role of MET in autism susceptibility.
Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suda S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N.
Neuroscience Research 2010 Jul; 68(2):137.
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Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis patients: beneficial roles of HGF in muscle regeneration.
Sugiura T, Kawaguchi Y, Soejima M, Katsumata Y, Gono T, Baba S, Kawamoto M, Murakawa Y, Yamanaka H, Hara M.
Clinical Immunology (Orlando, Fla.) 2010 May; 136(3):387.
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MET receptor sequence variants R970C and T992I lack transforming capacity.
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